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目的分析艾滋病患者抗病毒治疗前后CD4~+T淋巴细胞计数变化,为艾滋病免费抗病毒治疗工作提供依据。方法利用国家“艾滋病综合防治信息”系统收集宁波市鄞州区304例艾滋病患者资料,分析抗病毒治疗前后CD4~+T淋巴细胞计数变化。结果鄞州区304例艾滋病患者基线与治疗3、6、12、24和36个月后的CD4~+T淋巴细胞计数比较,均有不同程度增加(P<0.05);在治疗前3个月增幅最大,随着治疗时间延长增幅趋缓。秩相关分析显示,治疗36个月后CD4~+T淋巴细胞计数与基线水平相关(r=0.471,P<0.01)。结论高效抗反转录病毒治疗效果明显,早期治疗效果较好,应全面推进早检测、早诊断、早治疗工作。
Objective To analyze the change of CD4 ~ + T lymphocyte count before and after antiviral therapy in AIDS patients and provide the basis for the free anti-virus treatment of AIDS. Methods A total of 304 HIV / AIDS patients in Yinzhou District of Ningbo City were collected using the National AIDS Prevention and Control Information System to analyze the changes of CD4 ~ + T lymphocyte counts before and after antiviral treatment. Results The CD4 + T lymphocyte counts of 304 AIDS patients in Yinzhou District at baseline and after 3, 6, 12, 24 and 36 months of treatment were all increased to some extent (P <0.05). In the three months before treatment, The largest, with the treatment time to increase slowed down. Rank correlation analysis showed that CD4 ~ + T lymphocyte counts were correlated with baseline levels after 36 months of treatment (r = 0.471, P <0.01). Conclusion Highly effective antiretroviral therapy has obvious effect and early treatment effect is good. Early detection, early diagnosis and early treatment should be promoted in an all-round way.