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目的:复习文献对4例肌周细胞瘤(myopericytoma,MPC)的病理形态特点、组织发生、诊断和鉴别诊断、治疗及预后等做初步探讨。方法:标本采用常规石蜡切片,HE染色,另对石蜡切片采用EnVision免疫组化二步法染色。结果:男性和女性患者各2例,发病年龄21～58岁,平均发病年龄43.8岁,肿块无包膜。镜下特点为胞质嗜酸性的卵圆形及梭形瘤细胞围绕在薄壁小血管周围呈同心圆状排列,肿瘤的间质可见黏液变性。瘤细胞的胞质表达SMA弥漫阳性,Desmin局灶阳性。结论:肌周细胞瘤大多数为良性,生长缓慢,镜下见肿瘤最显著的特点为瘤细胞围绕在血管周围呈同心圆状排列,瘤细胞无明显的异型性及多形性,瘤细胞常表达肌源性标记阳性。肿瘤须与血管外皮瘤、血管平滑肌瘤及Kaposi型血管内皮瘤等相鉴别。
Objective: To review the literature on 4 cases of myopericytoma (MPC) pathological features, tissue, diagnosis and differential diagnosis, treatment and prognosis to do a preliminary study. Methods: The specimens were stained with HE and paraffin sections were stained with EnVision immunohistochemistry. Results: There were 2 males and 2 females with a mean age at onset of 21-58 years (mean age 43.8 years). Microscopic features of the cytoplasmic eosinophilic oval and spindle-shaped tumor cells around the thin-walled small blood vessels arranged in a concentric circle, visible interstitial tumor mucinous degeneration. The cytoplasm of tumor cells expressed diffusely positive SMA, Desmin focal positive. Conclusion: Most of myocystic tumors are benign and have slow growth. The most obvious feature of microscopic tumor is that the tumor cells are arranged concentrically around the blood vessels. The tumor cells have no obvious atypia and pleomorphism. Myogenic markers were positive. Neoplasms and hemangiopericytoma, angiomyolipoma and Kaposi type of endothelium and other phase identification.