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目的探讨肾综合征出血热(HFRS)患者血清可溶性P选择素(sP-选择素)水平的动态变化情况及其临床意义。方法用ELISA检测25例正常人和39例EHF患者四期(发热期、少尿期、多尿期及恢复期)血清sP-选择素水平。结果(1)EHF患者血清sP-选择素水平明显升高,且重症组高于轻症组；(2)少尿期及多尿期血清sP-选择素与血尿素和血肌酐均呈显著正相关(P＜0.01),血清sP-选择素与外周血血小板数呈显著负相关(P＜0.01)。结论血清sP-选择素作为重要的免疫分子参与HFRS的发病过程,动态检测HFRS患者血清sP-选择素水平,可作为HFRS病情观察的重要指标,同时也可为HFRS发病机制及防治研究提供线索。
Objective To investigate the dynamic changes of serum soluble P-selectin (sP-selectin) in patients with hemorrhagic fever with renal syndrome (HFRS) and its clinical significance. Methods Serum levels of sP-selectin in 25 cases of normal and 39 cases of EHF were detected by ELISA in four stages (fever, oliguria, polyuria and convalescence). Results (1) Serum sP-selectin levels were significantly elevated in patients with EHF, and were significantly higher in severe cases than in mild cases; (2) Serum sP-selectin and serum urea and serum creatinine were significantly positive in oliguria and polyuria (P <0.01). There was a significant negative correlation between serum sP-selectin and peripheral blood platelets (P <0.01). Conclusion Serum sP-selectin is an important immune molecule involved in the pathogenesis of HFRS. The dynamic detection of serum sP-selectin levels in HFRS patients may be an important indicator for the observation of HFRS. It may also provide clues for the pathogenesis and prevention and treatment of HFRS.