7例扩张型心肌病患者(NYHA分级为Ⅲ或Ⅳ级)接受静注心房利尿钠因子(ANF)3次治疗,剂量为50、100和200μg,每次注射间隔15分钟。第3次注射后20分钟,其中4例又静注ANF100μg一次,随后静滴ANF20μg/分30分钟。 静注ANF后,收缩压与舒张压出现同剂量有关的降低,但约15分钟后血压即回升至原来水平,在静滴期间血压降低不明显。在静注较大剂量后,末梢血管阻力减少和心输出量增加均较为显著。在所有各次静注后和在静滴期间,平均及舒张期肺动脉压和心率同基值相比均无显著改变。 Seven patients with dilated cardiomyopathy (NYHA class III or IV) received three injections of atrial natriuretic factor (ANF) at doses of 50, 100, and 200 μg with an interval of 15 minutes each. 20 minutes after the third injection, 4 of them were intravenously injected with ANF 100 μg once more, followed by intravenous infusion of ANF 20 μg / min for 30 minutes. After intravenous ANF, systolic and diastolic pressures were associated with dose-related reductions, but blood pressure returned to its original level after about 15 minutes, with no significant reduction in blood pressure during intravenous infusion. After intravenous injection of larger doses, peripheral vascular resistance decreased and cardiac output increased significantly. There was no significant change in mean and diastolic pulmonary artery pressure and heart rate over baseline values ​​after all intravenous and intravenous drip periods.