目的 :建立大鼠肺炎球菌型中耳炎模型 ,以观察其病程及病理变化。方法 :44只SD大鼠 ,向耳注入肺炎球菌悬液 ,定期观察 ,分批处死 ,观察中耳的病理变化。结果 :大部分实验鼠中耳炎表现为自限性疾病 ,但病程迁延较长。部分转为慢性中耳炎。鼓膜外观恢复正常的实验耳 ,于 6个月时仍有炎症改变。结论 :大鼠肺炎球菌性中耳炎并非完全是自限性疾病 ,其病理变化与人化脓性中耳炎类似 ,是研究人化脓性中耳炎较好的动物模型 Objective: To establish a rat model of pneumococcal otitis media to observe its course and pathological changes. Methods: Forty-four SD rats were injected with pneumococcal suspension into the ear and observed periodically and sacrificed. The pathological changes of the middle ear were observed. Results: Most of the experimental otitis media showed self-limiting disease, but the course of the disease lasted longer. Partially converted to chronic otitis media. Eardrum appearance returned to normal experimental ear, at 6 months there are still inflammatory changes. Conclusion: Pneumococcal otitis media is not a completely self-limiting disease in rats, and its pathological changes are similar to that of human suppurative otitis media. It is a good animal model for studying human suppurative otitis media