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二甲基甲酰胺(DMF)是一种广泛应用的工业原料。DMF的毒性与其在体内的代谢过程有关。CYP2E1是DMF的主要Ⅰ相代谢酶,Ⅱ相代谢酶谷胱甘肽-S-转移酶(glutathione S-transferase,GST)则可能在DMF的解毒过程中起重要作用。代谢酶的基因多态性对毒物的代谢及毒作用有较大的影响。本文就CYP2E1和GST基因多态性与DMF的代谢及毒性的关系进行综述。
Dimethylformamide (DMF) is a widely used industrial raw material. The toxicity of DMF is related to its metabolic processes in the body. CYP2E1 is the major phase I metabolizing enzyme in DMF, while glutathione S-transferase (GST), a phase II metabolizing enzyme, may play an important role in the detoxification of DMF. Genetic polymorphisms of metabolic enzymes have a greater impact on the metabolism and toxicity of toxicants. This article reviews the relationship between CYP2E1 and GST polymorphisms and the metabolism and toxicity of DMF.