视网膜母细胞瘤是儿童中一种常见的眼内恶性肿瘤,大约每出生17,000人到34,000人中有一人发病。一般认为这种肿瘤是遗传的,系谱分析可见到直接遗传、间接遗传、潜在突变嵌合体(Cryp-tic mosaics)、散发病例等几种形式,其中散发病例占大多数。关于视网膜母细胞瘤的发病机制,目前尚有争论。近年来,由于显带技术的应用,迄今已有20例关于视网膜母细胞瘤伴有13号染色体长 Retinoblastoma is a common intraocular malignant tumor in children and affects approximately one in 17,000 to 34,000 people at birth. It is generally considered that the tumor is inherited. Genealogy analysis shows that there are several forms of direct genetic, indirect inheritance, Cryp-tic mosaics, sporadic cases, and sporadic cases. On the pathogenesis of retinoblastoma, there is still controversy. In recent years, due to the application of the banding technology, so far there have been 20 cases of retinoblastoma associated with Chromosome 13