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片剂生产通常是先制成颗粒,然后压制成片。制粒通常要经过药料混和,加浆混匀,湿法制粒后再烘干等几道工序。流化床沸腾制粒新工艺,或称一步法制粒,可将这几道工序合成一道,故称一步法。国外早已投入生产,其技术关键是选择适宜的粘合剂,设计新处方及工艺条件。西德波林格曼药厂有几个品种的一步法制粒工艺,简介如下: 劳白醒药片(Raubasin)是一种降压和镇静药物,专利中透露的处方为:
Tablet production is usually first made of particles, and then pressed into tablets. Granulation usually through the mixture of medicine, plus pulp mixing, wet granulation and then drying several processes. Fluidized bed boiling granulation of new technology, or one-step granulation, these processes can be synthesized together, it said one-step method. Foreign countries have long been put into production, the key technology is to select the appropriate adhesive, the design of new prescriptions and process conditions. There are several varieties of step-by-step granulation processes in West Germany Pollingermann pharmaceuticals, which are summarized as follows: Raubasin is a hypotensive and sedative drug disclosed in the patent as: