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肿瘤坏死因子(Tumor NecrosisFactor,TNF)不仅对肿瘤细胞有细胞毒性作用,它还通过使内皮细胞ELAM及ICAM的表达水平升高、刺激趋化性因子及集落刺激因子的产生从而促进粒细胞粘附、血管和血细胞生长、提高前列环素的水平和促血小板凝集活性并同时减低凝血调素蛋白C的抗凝活性促进凝血及促进内皮细胞sis癌基因的表达等参与心血管系统细胞功能的调
Tumor necrosis factor (TNF) not only has cytotoxic effect on tumor cells, but also promotes granulocyte adhesion by increasing the expression of ELAM and ICAM in endothelial cells, stimulating the production of chemotactic factor and colony stimulating factor , Vascular and blood cell growth, increase the level of prostacyclin and promote platelet aggregation activity and at the same time reduce the anticoagulant activity of thrombospondin C, promote blood coagulation and promote endothelial cell sis oncogene expression involved in the regulation of cardiovascular system cell function