降糖药物二甲双胍（metformine）最近已在美国上市，用于治疗仅仅通过控制饮食而不能充分控制的非胰岛素依赖型糖尿病（NIDDM）。在此之前，此药已在90多个国家上市。二甲双胍基苯乙双胍类药物，但苯乙双胍引起的乳酸性酸中毒发生率很高，故于1976年被撤出美国市场。在批准二甲 Metformin, a hypoglycemic drug, has recently been marketed in the United States for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) that is not adequately controlled by diet alone. Prior to this, the drug has been listed in more than 90 countries. Metformin phenformin drugs, but the incidence of lactate acidosis caused by phenformin is very high, it was withdrawn in 1976 in the United States market. In the approval of the two