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本文用凝血酶亲和层析,制备电泳分离纯化了兔肺血栓调节蛋白(TM)。并对兔肺TM抑制血凝和血小板聚集,以及激活蛋白C 等作用进行了初步研究。结果表明,兔肺TM 的抗凝作用主要是抑制了内源性凝血系统,而对外源性凝血系统影响很小;并可通过蛋白C 系统起抗凝和纤溶作用;能完全抑制由凝血酶和瑞斯托霉素诱导的血小板聚集。
In this paper, thrombin affinity chromatography, the preparation of electrophoresis separation and purification of rabbit pulmonary thrombomodulin (TM). Rabbit lung TM inhibition of hemagglutination and platelet aggregation, and activation of protein C and other effects were studied. The results showed that the anticoagulant effect of rabbit lung TM mainly inhibits the endogenous coagulation system, but has little effect on the extrinsic coagulation system, and can act anticoagulant and fibrinolytic effect through the protein C system. It can completely inhibit the coagulation induced by thrombin And ristocetin-induced platelet aggregation.