本文以对硝基苯乙胺及取代苯甲醛为原料，经席夫氏碱还原，Ｎ取代反应、铁粉盐酸还原硝基、甲烷磺酰化五步反应，设计合成了１２个甲烷磺酰胺苯乙胺类衍生物。初步药理研究结果表明，这些化合物显示不同程度的抗心律失常活性，作用强度与Ⅲ类抗心律失常药Ｓｏｔａｌｏｌ相当 In this paper, p-nitrophenethylamine and substituted benzaldehyde as raw materials, Schiff base reduction, N-substituted reaction, iron  hydrochloric acid reduction of nitro, methane sulfonylation five-step reaction, design and synthesis of 12 methane sulfonates Amide phenethylamine derivatives. Preliminary pharmacological studies have shown that these compounds exhibit varying degrees of anti-arrhythmic activity with a magnitude comparable to that of the class III arrhythmic drug Sotalol