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目的了解母亲尿碘与新生儿尿碘及血促甲状腺激素(TSH)水平及相关性。方法选取695例母亲及其新生儿作为研究对象,采集母亲和新生儿尿液检测尿碘,采集新生儿足跟血检测TSH。结果 695例母亲的尿碘中位数为212.9μg/L,239例(34.39%)母亲尿碘<149μg/L为碘缺乏,143例(20.58%)母亲尿碘在150~249μg/L间为碘适量,163例(23.45%)母亲尿碘在250~499μg/L间为碘超足量,150例(21.58%)母亲尿碘≥500μg/L为碘过量;新生儿尿碘中位数为345.7μg/L;母亲尿碘水平与其新生儿尿碘呈正相关(r_s=0.576,P?<0.001);新生儿TSH为(3.24±1.75)m IU/L,其中88例(12.66%)TSH>5 m IU/L;母亲碘缺乏及碘过量的新生儿的TSH水平及TSH>5 m IU/L的比例均高于母亲碘适量或碘超足量的新生儿,差异有统计学意义(P<0.05)。结论本调查中母亲总体处于碘适量水平,但仍有较高比例的碘缺乏或碘过量;母亲尿碘水平与新生儿尿碘水平密切相关;碘缺乏或碘过量母亲生育高TSH新生儿的风险较高。
Objective To understand the urinary iodine and neonatal urinary iodine and thyroid stimulating hormone (TSH) levels and their correlation in mothers. Methods 695 mothers and their newborns were selected as research objects. Urine iodine was collected from urine collected from mothers and newborns and TSH was collected from newborn heel. Results The median urinary iodine of 695 mothers was 212.9 μg / L, and 239 (34.39%) mothers had urinary iodine <149 μg / L as iodine deficiency, and 143 (20.58%) mothers had urinary iodine between 150 and 249 μg / The urinary iodine of mothers in 163 (23.45%) pregnant women with iodine exceeded 250 ~ 499μg / L, and the iodine≥500μg / L in 150 mothers (21.58%) was iodine excess. The median urinary iodine of neonates was 345.7 μg / L; the urinary iodine level of mothers was positively correlated with the urinary iodine of newborn infants (r_s = 0.576, P <0.001); the TSH of newborns was (3.24 ± 1.75) mIU / L, of which 88 (12.66% 5 m IU / L; the neonatal TSH levels and TSH> 5 mIU / L of mothers with iodine deficiency and iodine excess were higher than those of mothers with iodine or iodine excess (P <0.05). Conclusion The mothers in this survey were generally at a moderate level of iodine but still had a high proportion of iodine deficiency or iodine excess; the urinary iodine level of their mothers was closely related to the level of urinary iodine in their newborns; the risk of neonatal hypothyroidism with iodine deficiency or excess iodine Higher.