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目的：探讨IL-6对1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的帕金森病（PD）小鼠模型是否具有治疗作用。方法采用脑室内注射 IL-6对MPTP诱导的PD小鼠模型进行治疗，首先进行行为学测试，而后采用免疫组织化学及蛋白印迹分析（western blot）的方法对 PD相关标志物酪氨酸羟化酶(TH)进行检测。结果①MPTP可以显著降低小鼠的转棒潜伏期，延长爬杆时间，IL-6可以改善这种效应；②黑质免疫组化染色显示：阳性对照组较正常对照组 TH阳性细胞数明显减少，治疗组可逐渐恢复TH 阳性细胞损失，中和抗体可以抵消这种效应；③纹状体Western blot结果显示：治疗组较阳性对照组TH表达明显增多。结论适当浓度的IL-6可以对MPTP诱导的小鼠PD模型产生明显的治疗作用。“,”Objective To investigate the ef ects of IL-6 on the functional and morphological outcome in a mice model of PD rendered by MPTP. Methods Male mice were treated with IL-6 for 3 days after MPTP administration, and were compared with saline-treated mice. Immunohistochemistry and western blot were used to detect the alterations of PD biomarker including tyrosine hydroxylase (TH). In addition, monoamine neurotransmit ers in the striatum of mice were measured by the high performance liquid chromatography (HPLC). Results Mice in MPTP-treated group had significant shorter rol ing bar test latency than other groups(P<0.05), and also manifested a longer pole-climbing time(P<0.05). IL-6 can improve the behavior of mice, while IL-6-neutralizing antibody can abrogate the ef ects. TH immunohistochemistry indicated that the number of dopaminergic neurons in the substantia nigra was increased in IL-6-treated mice. Western blot demonstrated the similar TH protein expression in striatum. Conclusion The appropriate concentration of IL-6 can MPTP-induced mouse model of PD have a significant therapeutic ef ect.