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本文用酶联免疫法(ELISA)对202例各类乙型肝炎病毒(HBV)感染者血清前S2蛋白(PreS2)和前S2抗体(抗PreS2)进行了检测。结果PreS2的阳性率为51.5％(104/202),抗PreS2为6.9％(14/202)。各型HBV感染者,PreS2的标化检出率无明显差异。在HBVDNA阳性组、HBeAg阳性组和PHSAR阳性组PreS2的检出率均明显高于阴性组。抗PreS2在急性乙型肝炎(AVH)恢复期的检出率为55.6％,高于慢性迁延性肝炎(CPH)的10.3％(P<0.005)。动态观察发现抗PreS2在AVH患者多产生于HBsAg、HBVDNA被清除后、抗-HBs产生前,这类患者预后较好。CPH患者抗PreS2的出现则提示HBV复制停止,病情稳定。
In this study, preS2 protein and PreS2 antibody (PreS2) were detected in 202 cases of various types of hepatitis B virus (HBV) infection by enzyme-linked immunosorbent assay (ELISA). Results The positive rate of PreS2 was 51.5% (104/202) and that of PreS2 was 6.9% (14/202). There was no significant difference in the detection rate of PreS2 among HBV infected patients. In HBVDNA-positive group, the detection rate of PreS2 in HBeAg-positive group and PHSAR-positive group was significantly higher than that in the negative group. The detection rate of anti-PreS2 in recovery of acute hepatitis B (AVH) was 55.6%, higher than that of chronic persistent hepatitis (CPH) 10.3% (P <0.005). Dynamic observation found that anti-PreS2 in patients with AVH more than HBsAg, HBVDNA was cleared, anti -HBs before the emergence of such patients with better prognosis. Presence of PreS2 in patients with CPH prompted the termination of HBV replication, stable condition.