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我国尚未建立降钙素的测定方法,但我国医药需要建立一个符合我国实际情况的方法,在国外目前一般采用 M.A.Kumar 氏法,用年龄不限;饮食不限的大白鼠,静脉注射标准品和测试品的降钙素,注射一小时前后测定血钙,根据降钙反应,用四点法计算降钙素的生物效价。我们将 Kumar 氏法加以改进,不同点为,采用了五周龄的大白鼠,给低钙饮食21小时,静脉注射降钙素后30分钟采血,测定血清钙,根据降钙反应,用四点法计算降钙素
China has not yet established a method for the determination of calcitonin, but the Chinese medicine needs to establish a method in line with China’s actual situation, the current general use of MAKumar’s method abroad, with an open age; diet unlimited rats, intravenous standard and Calcitonin test article, one hour before and after injection of serum calcium, calcitonin according to the four-point method to calculate the biological potency of calcitonin. We improved the Kumar’s method except that five-week-old rats were given a low-calcium diet for 21 hours, blood was drawn 30 minutes after intravenous injection of calcitonin, serum calcium was measured, and according to the calcium-lowering response, Calculated calcitonin method