A network-based cognitive training induces cognitive improvements and neuroplastic changes in patien

来源 :中国神经再生研究(英文版) | 被引量 : 0次 | 上传用户:kouton
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Cognitive impairments are commonly observed in patients with multiple sclerosis and are associated with lower levels of quality of life. No consensus has been reached on how to tackle effectively cognitive decline in this clinical population non-pharmacologically. This exploratory case-control study aims to investigate the effectiveness of a hypothesis-based cognitive training designed to target multiple domains by promoting the synchronous co-activation of different brain areas and thereby improve cognition and induce changes in functional connectivity in patients with relapsing-remitting multiple sclerosis. Forty-five patients (36 females and 9 males, mean age 44.62 ± 8.80 years) with clinically stable relapsing-remitting multiple sclerosis were assigned to either a standard cognitive training or to control groups (sham training and non-active control). The standard training included twenty sessions of computerized exercises involving various cognitive functions supported by distinct brain networks. The sham training was a modified version of the standard training that comprised the same exercises and number of sessions but with increased processing speed load. The non-active control group received no cognitive training. All patients underwent comprehensive neuropsychological and magnetic resonance imaging assessments at baseline and after 5 weeks. Cognitive and resting-state magnetic resonance imaging data were analyzed using repeated measures models. At reassessment, the standard training group showed significant cognitive improvements compared to both control groups in memory tasks not specifically targeted by the training: the Buschke Selective Reminding Test and the Semantic Fluency test. The standard training group showed reductions in functional connectivity of the salience network, in the anterior cingulate cortex, associated with improvements on the Buschke Selective Reminding Test. No changes were observed in the sham training group. These findings suggest that multi-domain training that stimulates multiple brain areas synchronously may improve cognition in people with relapsing-remitting multiple sclerosis if sufficient time to process training material is allowed. The associated reduction in functional connectivity of the salience network suggests that training-induced neuroplastic functional reorganization may be the mechanism supporting performance gains. This study was approved by the Regional Ethics Committee of Yorkshire and Humber (approval No. 12/YH/0474) on November 20, 2013.
其他文献
笔者基于“清阳实四肢”理论从头论治跟痛症34例,现报道如下.rn1 临床资料rn选择2018年12月至2019年12月云南中医药大学第三附属医院针灸科门诊跟痛症患者34例,其中男21例,女
结合针灸类课程相关教学环节的特点,探索思政教育的实施路径.在教学过程中要充分挖掘针灸类课程中蕴含的中国传统文化和医德医风等思想政治元素,强化医学生的思想政治素养和
分析国内外针灸推拿英语复合型人才的就业情况及就业优势.针灸推拿英语复合型人才(英语实验班、涉外方向等)就业率和深造率均高于一般针灸推拿学本科毕业生,其在国内就业具有
变应性疾病从病因论,均与风、热有关;从病机论,多为气血同病;从脏腑论,与阳明胃肠郁热关系密切,“风”“热”“气”“血”与“阳明”是变应性疾病病因病机的共性要素.通过查
患者,女,50岁.初诊日期:2018年11月5日.主诉:右手全掌烧灼伴触电样刺痛感、不能触碰 1 月余.现病史:2018年8月31日右前臂被玻璃割伤,于某医院急诊行右前臂清创、血管神经肌腱