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自噬是真核细胞中特有的生命现象,是胞浆大分子物质通过溶酶体途径自我降解的生物学过程,它广泛参与多种生理和病理过程,在促进细胞生存、维持细胞自我稳态方面起重要作用。目前很多研究表明,自噬和血液系统中多种肿瘤的关系密切,因此,通过自噬途径寻找新的肿瘤治疗靶点,是一种治疗肿瘤的新方法。该文主要综述了细胞自噬与血液肿瘤的研究进展。
Autophagy is a unique biological phenomenon in eukaryotic cells. It is a biological process of cytoplasmic macromolecules self-degrading through lysosomal pathway. It is widely involved in many physiological and pathological processes, promoting cell survival and maintaining cell self-homeostasis Play an important role. At present, many researches show that autophagy is closely related to many kinds of tumors in the blood system. Therefore, finding a new target for tumor therapy through autophagy is a new method for treating tumors. This review summarizes the progress of autophagy and hematologic malignancies.