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干细胞再生医学在器官组织修复中已凸现出非常重要的地位。通过外源性表达基因进行体细胞的重编程,是目前最有希望获得供移植细胞的方式。微环境对于移植细胞的存活、迁移、分化起决定性作用。内源性一氧化氮合酶抑制剂系统(ADMA/DDAH)不但在调控血管生成中起着关键性作用,而且对肌细胞的诱导分化和促进肌生成方面发挥重要作用。本文就ADMA/DDAH对重编程“功能性心肌细胞”的作用予以阐述。
Stem cell regenerative medicine has played a very important role in organ tissue repair. The reprogramming of somatic cells by exogenously expressed genes is by far the most promising way to obtain transplanted cells. Microenvironment plays a decisive role in the survival, migration and differentiation of transplanted cells. The endogenous nitric oxide synthase inhibitor system (ADMA / DDAH) not only plays a key role in the regulation of angiogenesis, but also plays an important role in the induction of myocyte differentiation and the promotion of myogenesis. This article describes the role of ADMA / DDAH in reprogramming “functional cardiomyocytes.”