论文部分内容阅读
许多药物的体内动力学与年龄有关,这是因为,随年龄增大其肾排泄能力及肝代谢药物的机能下降。对有效血药浓度范围窄的药物来说,由于体内药物动力学的改变,即使是常用剂量,也能发生毒性反应,但随意减少剂量,则可影响疗效。三环类抗忧郁症药阿米替林,老年患者经常使用,而且有效血浓度范围窄。为此,Schulz博士对它的动力学与年龄的关系进行了研究。志愿受试者分成青年(7人,平均年龄22岁)和
The in vivo kinetics of many drugs are age-related because their ability to excrete their kidneys and the functioning of liver-metabolizing drugs decreases with age. For drugs with a narrow range of plasma concentrations, toxic reactions can occur even at the usual dosage due to changes in the pharmacokinetics of the drug in vivo. However, reducing the dosage at will may affect the efficacy. Tricyclic antidepressants amitriptyline, elderly patients often use, and the effective range of blood concentrations narrow. To this end, Dr. Schulz studied the relationship between its kinetics and age. Volunteers were divided into youth (7, average age 22 years) and