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近年来,在应用野百合属植物农吉利(即野百合Crotalaria sessiliflora L.)治疗皮肤癌等恶性肿瘤,取得一定疗效后,曾自农吉利中分离出农吉利生物碱Ⅰ——农吉利甲素。经化学研究证明,系双稠吡咯啶生物碱——单猪屎豆碱(Monocrota-line)。实验性动物抑制试验表明,对S_(180)抑制率达45—62.5％,临床试用也取得较为满意的疗效。农吉利在我国分布尚广,但其种子细小,且农吉利生物碱含量较低(0.2％),不足应用。为了扩大药用资源,我们根据植物亲缘关系和化学成
In recent years, after applying the wild lily plant Cinnamon (Crotalaria sessiliflora L.) to treat malignant tumors such as skin cancer and obtaining a certain effect, the auspicious alkaloid I, aurelin, was isolated from Nongli. Chemical studies have shown that it is a monopyrrolidine alkaloid, Monocrota-line. Experimental animal inhibition test showed that the inhibition rate of S_(180) was 45-62.5%, and clinical trials also achieved satisfactory results. Nongzi is widely distributed in China, but its seeds are small, and the content of alkaloids in Aussie is low (0.2%), which is insufficient for application. In order to expand medicinal resources, we