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目的 :探讨血清HBVDNA水平与HBV标志物 (HBVM )表现模式、肝功能状态、肝脏病理的关系。方法 :对 467例乙肝肝炎病毒单纯感染的患者进行HBVDNA定量检测 ,同时检测其他乙型肝炎病原学标志物及肝功能 ,并对其中 80例患者进行肝穿刺病理检查。结果 :血清HBVDNA水平与HBVM表现模式有关 ,HBsAg与HbeAg的存在影响HBVDNA水平变化。血清谷丙转氨酶水平与HBVDNA水平无明显相关。 80例患者HBVDNA定量与肝脏病理学分析 ,HBVDNA定量与肝组织炎症及纤维化无明显相关。结论 :HBVDNA定量检测特异性强 ,灵敏度高 ,与HbeAg阳性有明显相关 ,是乙型肝炎诊断和观察抗病毒治疗的一项可靠的判断指标。但与肝组织炎症及纤维化无明显相关
Objective: To investigate the relationship between the serum HBVDNA level and the pattern of HBV markers (HBVM), liver function and liver pathology. Methods: 467 patients with simple infection of hepatitis B virus were assayed for HBVDNA, and other hepatitis B etiological markers and liver function were tested at the same time, and 80 of them were examined by liver biopsy. Results: Serum HBVDNA levels correlated with the pattern of HBVM expression. The presence of HBsAg and HbeAg affected the level of HBVDNA. Serum alanine aminotransferase levels and HBVDNA levels no significant correlation. Quantitative analysis of HBVDNA in 80 patients and liver pathological analysis, HBVDNA quantitative and liver inflammation and fibrosis no significant correlation. Conclusion: HBVDNA quantitative detection of strong specificity, high sensitivity, and HbeAg positive significantly related to the diagnosis and treatment of hepatitis B is an reliable indicator of antiviral therapy. However, there was no significant correlation between liver inflammation and fibrosis