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目的:研究绝经后女性高尿酸血症患者血浆中性激素结合球蛋白(sex hormone binding globulin,SHBG)水平与血尿酸水平的相关性。方法:选取绝经后女性404例,其中高尿酸血症组204例,正常对照组200例,测量所有研究对象体重、身高、腰围、臀围、收缩压(SBP)、舒张压(DBP),并计算体重指数(BMI)和腰臀比(WHR),检测血尿酸(UA)、空腹血糖(FBG)、总胆固醇(TG)、甘油三酯(TC)低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、雌激素(E2)、雄激素(T)、空腹胰岛素(INS)及SHBG,并计算胰岛素抵抗指数(Homa-IR)。结果:与绝经后女性尿酸正常者相比,高尿酸血症的患者UA,WHR,TC,FBG,INS,Homa-IR明显升高(P<0.01),DBP,WAIST和LDL升高(P<0.05),SHBG水平明显下降(P<0.01);SHBG与INS、UA、TG呈显著负相关(P<0.05),SHBG与E2呈显著正相关P<0.01)。结论:绝经后女性中高尿酸血症患者的低血浆SHBG水平与高血尿酸水平显著相关,血浆SHBG水平下降与胰岛素抵抗可能高度相关,低SHBG可能作为绝经后女性患高尿酸血症的高危因素。
Objective: To study the correlation between plasma levels of sex hormone binding globulin (SHBG) and serum uric acid in postmenopausal women with hyperuricemia. Methods: 404 postmenopausal women were selected, including 204 cases of hyperuricemia and 200 cases of normal control. Body weight, height, waist circumference, hip circumference, systolic pressure (SBP) and diastolic blood pressure (DBP) Body mass index (BMI) and waist-hip ratio (WHR) were measured. UA, FBG, TG, TC LDL, (HDL), estrogen (E2), androgen (T), fasting insulin (INS) and SHBG were measured and insulin resistance index (Homa-IR) was calculated. Results: The levels of UA, WHR, TC, FBG, INS and Homa-IR in hyperuricemia patients were significantly increased (P <0.01) and DBP, WAIST and LDL were increased in patients with hyperuricemia (P < 0.05), while SHBG level decreased significantly (P <0.01). There was a significant negative correlation between SHBG and INS, UA and TG (P <0.05). CONCLUSION: Low plasma SHBG level in hyperuricemia patients is significantly associated with hyperuricemia in postmenopausal women. The decrease of plasma SHBG levels may be closely related to insulin resistance. Low SHBG may be considered as a risk factor for hyperuricemia in postmenopausal women.