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目的:分析甲亢患者人格特征及与脑功能变化的关系。方法:35例甲亢患者纳入研究,男性9例,女性26例;平均年龄(38.74±10.57)岁;病程为1.5个月至9年。短病程组15例(病程小于等于6个月),长病程组20例(病程大于6个月)。正常对照者28例,男性8例,女性20例;平均年龄(35.8±9.41)岁。所有患者及正常对照均行静息~(99)Tc~m-ECD SPECT脑血流灌注显像。应用艾森克人格问卷(EPQ)分析人格特征;7例患者经治疗甲功正常后再次行人格特征分析及脑血流灌注显像。结果:甲亢患者具有高神经质及精神质的人格特征(P<0.05);不同病程患者人格特征无显著差异;治疗后患者人格特征评分无显著变化(P>0.05),但神经质维度N评分有明显减低趋势。甲亢患者高神经质评分与丘脑、海马旁回、后内嗅皮层、苍白球、乳头体血流灌注呈显著负相关(P<0.05)。结论:甲亢患者具有高精神质及神经质的个性特征,可能与其本身具有的不稳定个性特征及疾病导致的局部脑血流灌注减低、脑功能异常有关。
Objective: To analyze the relationship between personality traits and changes of brain function in patients with hyperthyroidism. Methods: Thirty-five patients with hyperthyroidism were enrolled in this study. There were 9 males and 26 females with an average age of (38.74 ± 10.57) years and a duration of 1.5 months to 9 years. Short course of disease in 15 cases (duration less than or equal to 6 months), long course of 20 cases (duration of more than 6 months). 28 cases of normal control, 8 males and 20 females; mean age (35.8 ± 9.41) years. Resting ~ (99) Tc ~ m-ECD SPECT cerebral perfusion imaging was performed in all patients and normal controls. Personality characteristics were analyzed by EPQ. Seven patients were reformed with personality traits and cerebral perfusion imaging after treatment of normal thyroid function. Results: The patients with hyperthyroidism had high neuroticism and psychotic personality (P <0.05). There was no significant difference in personality traits among patients with different course of disease. There was no significant change in personality traits after treatment (P> 0.05), but N score of neuroticism was significant Reduce the trend. Hyperthyroidism patients with high neurotic score and the thalamus, parahippocampal gyrus, posterior entorhinal cortex, globus pallidus, papillary body perfusion was significantly negatively correlated (P <0.05). CONCLUSION: Hyperthyroidism patients with high mental quality and neurotic personality traits may be related to its own unstable personality characteristics and disease caused by decreased local cerebral perfusion, abnormal brain function.