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目的:分析1962 - 2018年甘肃省黄鼠疫源地鼠鼠疫自然疫流行病学特征，为鼠疫防控提供依据。方法:整理1962 - 2018年甘肃省黄鼠鼠疫自然疫源地疫情监测资料和疫情总结资料，采用描述性统计方法对鼠疫流行病学特征进行分析，包括人群地区分布、时间分布和动物地理分布、染疫动物及媒介等。结果:1962 - 2018年，甘肃省黄鼠疫源地内仅1962年发生1起人间鼠疫，本次疫情共发病26例，死亡11例，发病率为29.89%（26/87），病死率为42.31%（11/26）。病例主要分布在会宁县刘寨乡、新塬乡，发病时间为7 - 8月份。1962 - 2018年，甘肃黄鼠疫源地共出现2次动物间鼠疫流行高峰，检菌地区分布于会宁县刘寨乡北部地区及接壤的平川区种田、复兴2个乡镇，判定动物疫点5处。染疫动物种类为黄鼠和沙狐，染疫媒介种类为方形黄鼠蚤蒙古亚种和阿巴盖新蚤，动物鼠疫流行时间为4 - 8月份；黄鼠血清F1抗体阳性115份，其中会宁县检出阳性血清92份、平川区检出阳性血清23份，分布于2个县（区）5个乡镇的11个村；疫源地内共发现动物30种，隶属5目11科5亚科21属，黄鼠占绝对优势，占历年调查啮齿类动物总数的69.1%（2 464/3 567）；共调查疫源地12 482.9 hmn 2，捕黄鼠9 709只，平均密度为0.78只/hmn 2。n 结论:甘肃黄鼠鼠疫自然疫源地鼠疫呈间歇性流行状态，应根据变化情况及时调整防控策略，在居民区应主动加强鼠情监测和人间鼠疫防护知识的宣传教育。“,”Objective:To analyze the dynamics of plague epidemic in n Spermophilus alaschanicus plague foci of Gansu Province from 1962 to 2018, and to provide evidence for plague control and prevention.n Methods:The data of n Spermophilus alaschanicus plague in Gansu Province from 1962 to 2018 were collected and organized from epidemic surveillance and epidemic summary. The method of descriptive epidemiology was used to analyze plague, including population (regional distribution, time distribution) and animal (geographic distribution, infected animals and vectors) epidemiology.n Results:There was only one case of human plague in the n Spermophilus alaschanicus plague foci of Gansu Province from 1962 to 2018. The total incidence of the disease was 26 cases, 11 cases died, the incidence rate was 29.89% (26/87), and the mortality was 42.31% (11/26). The cases were mainly distributed in Liuzhai Township and Xinyuan Township of Huining County. The outbreak occurred from July to August. Plague bacteria were isolated from the plague foci of Gansu Province during two peak epidemics of the plague among animals from 1962 to 2018. The bacteria detection area was located in 2 rural areas that were the northern area of Liuzhai in Huining County, and the neighboring Zhongtian and Fuxing in Pingchuan District. Five places were determined to be the animal epidemic sites. The endemic species were n Spermophilus alaschanicus and n Vulpescorsac, and the vector species were n Citellophilus tesquorus mongolicus and n Neopsylla abagaitui. The epidemic time of animal plague was from April to August. Totally 115 positive serum F1 antibodies were obtained. Among them, 92 positive serum samples were detected in Huining County and 23 in Pingchuan District. The positive blood coagulation sites were distributed in 11 villages, 5 towns of 2 counties (districts). The surveillance results showed that 30 species of animals belonging to 5 orders, 11 families, 5 subfamilies, and 21 genera were found in the foci, most of them were n Spermophilus alaschanicus, which accounting for 69.1% (2 464/3 567) of the total species of rodents in the past years. A total of 12 482.9 hmn 2 were investigated by sampling method, and 9 709 n Spermophilus alaschanicus were captured, with an average density of 0.78/hmn 2.n Conclusions:The plague is intermittently prevalent in Gansu'sn Spermophilus alaschanicus plague foci. So the prevention and control strategies should be adjusted in time according to the changes. In residential areas, we should take the initiative to strengthen the monitoring of rat situation and the publicity and education of human plague prevention knowledge.n