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目的 探讨两种重组血红蛋白及清蛋白对失血性休克的治疗效果。方法 2 4只大鼠随机等分为 3组 ,由股动脉抽血建立失血性休克模型 ,保持平均动脉压 (MAP) 4 0mmHg 4 5min。休克后对照组输入人体清蛋白 (HSA) ,其他两组分别输入重组血红蛋白rHb1.1和rHb2 .0。测定休克前后不同时间点MAP、肠系膜上动脉血流、股动脉血气和肠纱膜上静脉血气值。结果 rHb1.1输入后 30minMAP显著高于休克前 (P <0 .0 1)和其他两组 (P <0 .0 5 ) ;在休克后各时间点上 ,肠系膜上动脉血流量接近休克前水平 ,但显著低于rHb2 .0和HSA组 (P <0 .0 1)。重组血红蛋白可恢复并维持MAP休克前水平 6 0～ 90min ,清蛋白只能维持30min。动脉及肠系膜上静脉血气分析显示两种重组血红蛋白治疗效果相似 ,显著高于HSA组 (P <0 .0 5 )。结论 重组血红蛋白治疗失血性休克效果优于清蛋白 ,rHb2 .0是较理想的血液替代品。
Objective To investigate the therapeutic effects of two recombinant hemoglobin and albumin on hemorrhagic shock. Methods 24 rats were randomly divided into three groups. The model of hemorrhagic shock was established by drawing blood from the femoral artery and keeping the mean arterial pressure (MAP) at 40 mmHg for 45 min. The control group after shock, enter human albumin (HSA), the other two groups were imported recombinant hemoglobin rHb1.1 and rHb2 .0. Before and after shock at different time points MAP, superior mesenteric artery blood flow, femoral artery blood gas and veins venous blood gas values. Results The MAPAP at 30 min after rHb1.1 injection was significantly higher than that before shock (P <0.01) and the other two groups (P <0.05). At each time after shock, the superior mesenteric artery blood flow approached the level before shock , But significantly lower than rHb2. 0 and HSA group (P <0. 01). Recombinant hemoglobin can restore and maintain MAP before shock level 60 ~ 90min, albumin can only maintain 30min. Arterial and superior mesenteric vein blood gas analysis showed that the two recombinant hemoglobin treatment effect was similar, significantly higher than HSA group (P <0.05). Conclusion Recombinant hemoglobin is better than albumin in the treatment of hemorrhagic shock, rHb2. 0 is an ideal blood substitute.