用放射免疫法对３２例流行性出血热患者血浆心钠素、β２ｋ微球蛋白进行了动态检测，结果显示：心钠素含量明显增加，与健康及高热性疾病对照组有显著差别，在病程中呈规律性变化，同病情轻重一致，与肾脏损害程度密切相关。但显著增高的心钠素未能发挥其应有的利尿、降压作用。血浆心钠素增高的主要原因可能是肾脏心钠素受体严重受损及降解酶功能被抑制有关 By radioimmunoassay in 32 cases of epidemic hemorrhagic fever plasma atrial natriuretic peptide, β2k microglobulin dynamic test results showed: atrial natriuretic peptide increased significantly, and health and hyperthermia disease control group were significantly different in the course of disease In the regular changes, consistent with the severity, and the degree of renal damage are closely related. However, significantly increased atrial natriuretic peptide failed to play its due diuretic, antihypertensive effect. The main reason for the increase in plasma atrial natriuretic peptide may be related to the severe impaired renal atrial natriuretic peptide receptors and the inhibition of degradative enzyme function