论文部分内容阅读
目的 测定并比较Ⅱ型糖尿病有、无并发症组及正常对照组的血浆心钠素 (ANP)水平 ,以探讨ANP在Ⅱ型糖尿病患者发病机理与临床意义。方法 采用放射免疫法测定ANP并比较与空腹胰岛素、糖化血红蛋白、左房前后径、右房横径等的关系。结果 Ⅱ型糖尿病有并发症组较无并发症组左房前后径、右房模径有显著增大 (P <0 .0 1) ,ANP显著增高 (P <0 .0 1) ,且有并发症组ANP与相应的左房前后径、右房大小呈正相关 ,Ⅱ型糖尿病无并发症组较正常对照组左、右心房内径无显著性差异 (P <0 .0 5 )。结论 血浆ANP可作为对Ⅱ型糖尿病患者了解病情及估计预后一项参考指标。
Objective To determine and compare the level of plasma atrial natriuretic peptide (ANP) in type Ⅱ diabetic patients with and without complications and to compare the pathogenesis and clinical significance of ANP in type Ⅱ diabetic patients. Methods ANP was determined by radioimmunoassay and compared with fasting insulin, glycosylated hemoglobin, left atrium anteroposterior diameter and right atrial diameter. Results Compared with the non-complication group, the left and right atrium diameters, the right atrium model diameter and the ANP were significantly increased in type 2 diabetes mellitus group (P <0.01, P <0.01) There was a positive correlation between ANP and left ventricular anteroposterior diameter and right atrium size in the syndrome group. There was no significant difference in the diameters of left and right atria between the non-complication group and the normal control group (P <0.05). Conclusion Plasma ANP can be used as a reference index to understand the condition of patients with type 2 diabetes and prognosis.