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像其他地中海国家一样,土耳其的乙型肝炎病毒(HBV)感染呈地方性流行,儿童感染率高.在血液病(如地中海贫血、血友病和癌症)患者中,HBV感染可能与多次输血和医院密切接触有关.细胞毒治疗也可改变患者对HBV感染的免疫应答.大量资料表明,HBV疫苗对健康儿童和青年预防感染效果在90%以上.由于疫苗价格昂贵,土耳其没有规定常规婴儿HBV疫苗免疫政策.作者对70例恶性血液病、26例地中海贫血、20例血友病和26例其他血液病(缺铁性贫血和免疫性血小板减少性紫癜)患儿进行了研究.自1991年至1995年间在Ege大学医院随访观察,142名儿童HBsAg、抗-HBs和抗-HBc均阴性.重组HBV疫苗(Gen Hevac B,法国巴
Like other Mediterranean countries, Hepatitis B virus (HBV) is endemic in Turkey and has a high prevalence in children, and may be associated with multiple transfusions in patients with blood diseases such as thalassemia, hemophilia and cancer And close contact with the hospital.Cytotoxicity therapy can also change the patient’s immune response to HBV infection.Many data show that the effect of HBV vaccine on healthy children and young people to prevent infection in more than 90% .Because the vaccine is expensive, Turkey does not require conventional infant HBV Vaccine Immunization Policy The authors studied 70 children with hematologic malignancies, 26 with thalassemia, 20 with hemophilia and 26 with other hematological disorders (iron-deficiency anemia and immune thrombocytopenic purpura). Since 1991 A total of 142 children were negative for HBsAg, anti-HBs and anti-HBc by follow-up at Ege University Hospital from 1995 to 1995. Recombinant HBV vaccine (Gen Hevac B,