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目的探讨孕期糖尿病与血清25-OH维生素D的关系。方法随机选取我院门诊行常规产前检查的孕妇300例为研究对象,参照ADA标准诊断GDM为26例,另选取同期正常孕妇26例为对照组,比较两组血清25-OH维生素D变化水平。结果 GDM组的BMI与对照组比较差异有统计学意义(P<0.05),孕妇血清25-OH维生素D含量测定,GDM组含量明显高于对照组(P<0.05);两组孕前BMI的均值为22.99,血清25-OH维生素D浓度的均值为52.12,经相关性分析,r=0.32,P=0.005。结论孕妇血浆25-OH维生素D水平变化与GDM发病及病情发展有关,对早期预测GDM具有积极的意义。
Objective To investigate the relationship between diabetes and serum 25-OH vitamin D during pregnancy. Methods A total of 300 pregnant women with routine prenatal examination in our outpatient department were randomly selected for the study. According to ADA criteria, GDM was diagnosed in 26 cases. Another 26 pregnant women were selected as control group. The changes of serum 25-OH level in both groups were compared . Results The BMI in GDM group was significantly different from that in control group (P <0.05). The serum 25-OH level in pregnant women was significantly higher than that in control group (P <0.05). The mean BMI before pregnancy Was 22.99. The average serum 25-OH vitamin D concentration was 52.12. Correlation analysis showed r = 0.32, P = 0.005. Conclusion The change of plasma 25-OH level in pregnant women is related to the pathogenesis of GDM and the development of GDM. It has positive significance for the early prediction of GDM.