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目的:探讨胰岛素样生长因子-1对大鼠肝纤维化形成的影响.方法:50只SD大鼠随机编入4组,正常组和橄榄油组各10只,模型组15只,IGF-1干预组15只.40%CCL4橄榄油溶液制备大鼠肝纤维化模型,4wk后,以IGF-12ug/kg干预,共2wk.观察大鼠存活率、体重变化及纤维化形成率;光镜下观察大鼠肝组织病理及胶原纤维变化;采用Western-blot法检测肝组织中α-肌动蛋白(α-SMA)含量.结果:IGF-1干预组大鼠存活率高于模型组,体重(301.5±32.4g)明显高于模型组(252.1±24.1g,P<0.05),肝纤维化形成率较模型组低,光镜下肝组织纤维化程度明显改善,胶原含量明显下降.IGF-1干预组中肝组织α-SMA含量明显低于模型组.结论:IGF-1具有抗大鼠肝纤维化作用,这可能与其改善肝功能、抑制HSC活化等有关.
Objective: To investigate the effect of insulin-like growth factor-1 on hepatic fibrosis in rats.Methods: Fifty Sprague-Dawley rats were randomly divided into four groups: normal control group (n = 10) and olive oil group The rats in the intervention group were treated with 40% CCL4 olive oil solution for 4 weeks, then treated with IGF-12ug / kg for 2 weeks. The survival rate, body weight and fibrosis rate were observed. The changes of hepatic tissue pathology and collagen fibers in rats were observed, the content of α-SMA in liver tissue was detected by Western-blot.Results: The survival rate of rats in IGF-1 intervention group was higher than that of model group, body weight 301.5 ± 32.4g) was significantly higher than that of the model group (252.1 ± 24.1g, P <0.05). The incidence of hepatic fibrosis was lower than that of the model group, and the degree of hepatic fibrosis was significantly improved under the light microscope. The level of α-SMA in the liver tissue of the intervention group was significantly lower than that of the model group.Conclusion: IGF-1 has anti-hepatic fibrosis effect, which may be related to its improvement of liver function and inhibition of HSC activation.