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目的:建立腰神经根压迫症动物模型,探讨针刺对模型大鼠受损腰神经根超微结构及炎性介质的影响.方法:将模型大鼠随机分为A组(模型组)45只和B组(模型+电针组)45只,A、B组分别于造模(电针)后15 d和30 d,取压迫区受损腰神经根组织经处理后于电镜和光镜下观察,同时测定其PGE2及5-HT的含量.结果:15 d后,与A组相比,B组大鼠神经纤维周围充血、水肿及神经根纤维脱髓鞘变较轻,雪旺氏细胞结构基本正常,30 d后,B组大鼠脱髓鞘变和神经内水肿较轻.B组大鼠受压神经根局部组织内PGE2和5-HT明显低于A组.结论:电针可缓解受损腰神经根周围炎性反应,改善腰神经根超微结构.,Objective: To establish the animal model of the compressed lumbar nerve and investigate the effect of acupuncture to the ultra-micro structure of the injured rat lumbar nerve and inflammatory medium. Method: Separate the laboratory rats into Group A (model group, n= 45) and Group B (model + electroacupuncture group, n = 45). observe injured lumbar nerve tissue with optic microscope and electron microscope and measure the content of PGE2 and 5-HT. Results: Hyperemia around the nerve tissue, edema and nerve root demyelination of electroacupuncture 15 day (Group B) is less than model group 15 day (Group A). The structure of Schwann cell is normal. Demyelination of electroacupuncture 30-day group (Group B) becomes slight and the nerve edema alleviates. In the Group B,contents of PGE2 and 5-HT after electroacupuncture obviously decrease compared to the Group A. Conclusion: Electroacupuncture can alleviates inflammatory reaction around the injured lumbar nerve and improve the ultra-micro structure of lumbar nerve root.