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粉防己为常用中药,主要含汉防己甲素(Tetrandrine以下简称甲素),汉防己乙素等十余个生物碱。其中甲素的生理活性最强,且含量最高,现代药理学对其的研究虽已半个世纪,但至今仍非常活跃。近年,人们对它的抗钙作用及其在心血管系统和抗矽肺的作用机理进行了研究取得了一定成果,本文对此作一简要介绍。 一、对循环系统作用 (一)对心脏功能的影响 甲素能降低猫心乳头肌、豚鼠心房的收缩力,显著抑制肾上腺素诱发自律性,延长功能性不应期,而对兴奋性则无影响;氧耗量则随甲素的浓度增高而逐渐下
Fen Fang Ji for the commonly used traditional Chinese medicine, mainly containing tetrandrine (Tetrandrine hereinafter referred to as A), tetrandrine and other more than ten alkaloids. Among them, A has the strongest physiological activity and the highest content. Although modern pharmacology has been studying it for half a century, it is still very active. In recent years, people have made some achievements on its anti-calcium effect and its mechanism in the cardiovascular system and anti-silicosis. This article gives a brief introduction. A, the role of the circulatory system (a) the impact on heart function A can reduce the cat heart papillary muscle, guinea pig atrial contractility, significantly inhibited adrenaline-induced self-regulation, to extend the functional refractory period, while the excitability is not Influence; Oxygen consumption increases with the concentration of A and gradually under