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目的探析对存在因各种原因引发的强烈疼痛患者用氨酚羟考酮片进行治疗的干预效果及药物不良反应情况。方法纳入于2015-2017年期间本院收治的因不同情况导致疼痛且需要治疗干预的患者的相关临床数据,从中选取60例,根据患者入院时间先后编序,采用随机数字表法以每组30例分为对照组与观察组,分别接受常规疼痛治疗、联合氨酚羟考酮片治疗,记录和随访患者疼痛改善效果以及出现药物不良反应情况。结果分别在患者治疗前、治疗后7天及治疗后1个月等不同时间段进行视觉模拟评分(VSA)对疼痛进行评估,提示治疗后患者VAS评分均有所改善,随着时间延长疼痛缓解效果逐渐明显,观察组治疗后VSA评分相对更具优越性,差异经统计学软件处理,提示(P<0.05);治疗后对患者进行平均2周时间的随访,期间患者均未出现导致疗程中断的严重不良反应,经对症处理后症状得到缓解,组间并发症发生率对比经统计学软件处理,提示(P>0.05)。结论对存在影响正常生活疼痛症状的患者应用氨酚羟考酮片进行治疗对于缓解相关症状以及提高患者生活质量有积极意义,同时治疗期间无相关不良反应,保障了患者治疗的依从性,值得临床推广。
Objective To explore the intervention effect and adverse drug reaction of oxycodone in patients with severe pain caused by various reasons. Methods Sixty cases were selected from the clinical data of patients in our hospital who had pain due to different conditions and needed treatment intervention during the period of 2015 to 2017. According to the sequence of patients admitted to hospital and the random number table Cases were divided into the control group and the observation group, respectively, receiving conventional pain treatment, combined with oxycodone tablets treatment, record and follow-up pain relief in patients with adverse drug reactions. Results Visual analogue scale (VSA) was used to evaluate the pain in patients before treatment, 7 days after treatment and 1 month after treatment, respectively. The results showed that the VAS scores improved after treatment, and the pain relief The effect was obvious, the observation group after treatment VSA score relative more superior, the difference was statistically processed software, suggesting (P <0.05); after treatment, patients were followed up for an average of 2 weeks, during which patients did not appear to lead to interruption of treatment Of the serious adverse reactions, symptomatic treatment after the symptoms were alleviated, comparisons of complication rates between groups by statistical software, suggesting (P> 0.05). Conclusions The use of oxycodone for treatment of patients with symptomatic pain in normal life is of positive significance in alleviating related symptoms and improving the quality of life of patients. At the same time, there is no adverse reactions during the treatment, which ensures the compliance of the patients and is worth clinical treatment Promotion.