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小儿艾滋病的主要临床体征是生长停滞,机会感染和淋巴性间质性肺炎。最近报导成人人免疫缺陷病毒(HIV)感染时,淋巴肉瘤、非何杰金淋巴瘤的发病数正在增多。本文报道一例儿童HIV感染与EB病毒(EBV)相关的B细胞Burkitt淋巴瘤的临床、病理及分子学特征。病例 4岁黑人男孩。足月产,其母有静脉滥用药物史。以患儿发热数日,腹痛、呕吐、厌食、腹围增大入院。2岁以内健康。曾以怀疑病毒性肺炎住院。有全身淋巴结肿大、肝大、生长停滞。免疫学检查:多克隆高γ球蛋白血症,辅助T细胞(T_4)与抑制T细胞(T_3)比值倒置。血清HIV抗体阳性。此次以怀疑病毒性肺炎再次住院。查体:无热,营养低下,身
The main clinical signs of childhood AIDS are stagnant growth, opportunistic infections and lymphatic interstitial pneumonia. Recent reports of adult human immunodeficiency virus (HIV) infection, lymphosarcoma, non-Hodgkin’s lymphoma incidence is increasing. This article reports a case of childhood HIV infection with Epstein-Barr virus (EBV) -related B-cell Burkitt lymphoma clinical, pathological and molecular features. Case 4 year old black boy. Full-term birth, the mother has a history of intravenous drug abuse. Children with fever days, abdominal pain, vomiting, anorexia, abdominal circumference increased admission. Healthy within 2 years old. Was suspected of viral pneumonia hospitalization. There are systemic lymphadenopathy, hepatomegaly, growth arrest. Immunological examination: Polyclonal hypergammaglobulinemia, the ratio of helper T cells (T_4) to T cells (T_3) was inverted. Serum HIV antibody positive. This time with suspected pneumonia again hospitalized. Physical examination: no heat, low nutrition, body