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探讨围产期新生儿脐血与静脉血瘦素水平的变化及其在胎儿、新生儿发育成熟中作用。方法 采用放射免疫法 ( RIA)检测孕母外周静脉血、新生儿脐血与周静脉血瘦素水平 ,采用 weststrate公式 [F% =0 .8848×SFT4+0 .0 2 2 ]估测新生儿体脂含量。结果 6 5例脐血瘦素水平 ( x±s) 1 0 .5 0± 3.45 ng/ml,73例新生儿外周静脉血瘦素水平 ( x± s) 2 .39± 1 .1 5 ng/ml。脐血瘦素水平与孕母外周血瘦素水平无显著相关 ( γ=0 .1 1 ,p>0 .0 5 ) ,与胎盘重量显著相关 ( γ=0 .71 ,p<0 .0 1 )。新生儿外周静脉血瘦素水平与新生儿体脂含量无显著相关 ( γ=0 .2 1 ,p>0 .0 5 ) ,与喂养方式显著相关 ,母乳喂养新生儿外周静脉血瘦素水平显著高于配方乳喂养 ( p<0 .0 1 )。结论 胎盘是脐血瘦素的主要来源 ,母乳是新生儿静脉血瘦素的重要来源 ;围产期新生儿脐血、静脉血瘦素水平的动态变化可能与新生儿宫外生存条件的变化与适应有关。
To investigate the changes of cord blood and venous blood leptin in perinatal neonates and its role in the development of fetus and newborn. Methods Radioimmunoassay (RIA) was used to detect peripheral blood leucorrhea levels in peripheral blood of pregnant women, cord blood of neonates and peripheral venous blood. Weststrate formula [F% = 0.8848 × SFT4 +0.022] was used to evaluate newborns Body fat content. Results Serum leptin levels (X ± s) were 0.55 ± 3.45 ng / ml in 65 cases, peripheral blood leptin levels in 73 neonates were (2. ± 1.5) ml. There was no significant correlation between cord blood leptin level and the level of leptin in pregnant women (γ = 0.11, p> 0.05), which was significantly associated with placental weight (γ = 0.71, p <0.01 ). Neonatal peripheral blood leptin levels and neonatal body fat content was not significantly correlated (γ = 0.21, p> 0.05), and feeding was significantly related to breast-fed peripheral blood leptin levels were significantly Higher than formula fed (p <0.01). Conclusion The placenta is the main source of cord blood leptin, breast milk is an important source of neonatal intravenous leptin; perinatal neonatal umbilical blood, venous blood leptin levels may be related to dynamic changes in neonatal ectopic survival conditions and Adapt to.