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目的:探讨枯草杆菌二联活菌(妈咪爱)对防治早产儿坏死性小肠结肠炎(NEC)的临床意义。方法:将2009年11月～2011年4月住院的250例早产儿按病例对照研究分预防组126例和对照组124例,两组除病因治疗、合理喂养外,预防组在24 h内加妈咪爱口服。结果:预防组中4例诊断为NEC,患病率为3.17%;对照组中18例诊断为NEC,患病率为14.52%.预防组早产儿的NEC患病率明显低于对照组,差异有统计学意义(P<0.05)。结论:预防性应用枯草杆菌二联活菌可明显降低早产儿NEC的发生,可能与枯草杆菌二联活菌可促进早产儿肠道正常菌群的定植和优势化有关。
Objective: To investigate the clinical significance of Bacillus subtilis two live bacteria (Mommy love) in the prevention and treatment of neonatal necrotizing enterocolitis (NEC). Methods: A total of 250 preterm infants hospitalized from November 2009 to April 2011 were divided into prevention group (126 cases) and control group (124 cases) according to the case-control study. Except for the cause of disease and reasonable feeding, the two groups were treated within 24 hours Mommy love oral. Results: In the prevention group, 4 cases were diagnosed as NEC with a prevalence of 3.17%, while 18 cases in the control group were diagnosed as NEC with a prevalence of 14.52% .NEC prevalence in preterm infants in prevention group was significantly lower than that in control group There was statistical significance (P <0.05). Conclusion: The prophylactic use of B. subtilis viable combined with B. subtilis can significantly reduce the occurrence of NEC in preterm infants. It may be related to the combination of B. subtilis and B. subtilis to promote the colonization and predominance of normal intestinal flora in preterm infants.