目的　探讨肾移植术后妊娠对移植肾的影响。方法　对 1 978年 4月至 2 0 0 2年 3月妊娠超过 5个月的 1 3例肾移植受者资料进行回顾性分析。结果　免疫抑制方案 ,4例采用环孢素A(CsA)及泼尼松 (Pred) ,5例为CsA、霉酚酸酯 (MMF)及Pred ,4例为他克莫司 (FK50 6)、MMF及Pred。 1 3例中 ,1 0例患者妊娠足月、生产 ,母、婴均存活 ,移植肾功能稳定 ;1例产后 2周因并发肺部感染、心力衰竭死亡 ,死亡时移植肾有功能 ,婴儿存活 ;2例妊娠中期出现蛋白尿 ,病理证实移植肾发生慢性排斥反应 ,终止妊娠 ,但抗排斥治疗无效 ,切除移植肾 ,恢复血液透析。目前 1 1名子女健康 ,无发育异常。结论　肾移植患者若情况允许 ,在严密监护下是可以妊娠的 Objective To investigate the effect of pregnancy after kidney transplantation on renal graft. Methods A retrospective analysis of data on 13 renal transplant recipients who had been pregnant for more than 5 months between April 1, 1978 and March 2, 2002 was performed. Results Four immunosuppressive regimens were CsA and Pred, five were CsA, MMF and Pred, four were FK506, MMF and Pred. In 13 cases, 10 maternal and infant survivors were born at term of full pregnancy, and the function of kidney graft was stable. One patient died of heart failure and died of pulmonary infection after 2 weeks of delivery, ; 2 cases of proteinuria in the second trimester of pregnancy, the pathology confirmed chronic rejection of graft kidney, termination of pregnancy, but the anti-rejection therapy is ineffective, removal of kidney transplant and recovery of hemodialysis. Currently 1 1 children healthy, no dysplasia. CONCLUSIONS: Patients with kidney transplants may be pregnant under strict surveillance if the situation permits