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目的:观察灯盏花素联合卡托普利治疗高血压早期肾损害的疗效。方法:将168例高血压病患者随机分成治疗组(84例)和对照组(84例),两组均给予卡托普利控制血压,治疗组另加用灯盏花素20 ml加入生理盐水250 ml静脉滴注,每日1次,观察治疗1个月后有关指标变化。结果:两组治疗前后自身对比,24 h尿微量白蛋白排泄(UAE)均有显著性下降(P<0.05);与对照组相比,治疗组UAE下降更为明显(P<0.05)。治疗前后血肌酐及尿素氮均无明显的变化(P>0.05);治疗组总有效率86.1%,对照组总有效率为50%,治疗组疗效明显高于对照组,差异有统计学意义(P<0.05)。结论:灯盏花素联合卡托普利对高血压病早期肾损害有一定疗效,值得推广。
Objective: To observe the efficacy of breviscapine and captopril in the treatment of early renal damage in patients with hypertension. Methods: A total of 168 patients with essential hypertension were randomly divided into treatment group (84 cases) and control group (84 cases). Both groups received captopril control blood pressure. The treatment group received another 20 ml of breviscapine and saline 250 ml intravenous drip once a day to observe changes in the index after 1 month of treatment. Results: Compared with the control group, UAE decreased significantly (P <0.05) 24 h urinary albumin excretion (UAE) in both groups before and after treatment. Before and after treatment, serum creatinine and urea nitrogen had no significant change (P> 0.05). The total effective rate was 86.1% in the treatment group and 50% in the control group, and the therapeutic effect in the treatment group was significantly higher than that in the control group P <0.05). Conclusion: Breviscapine combined with captopril has some effects on early renal damage in hypertensive patients and is worth promoting.