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研究甲苯与顺铂对豚鼠听力的影响，发现甲苯或顺铂单独作用后可造成豚鼠一定程度的听力损失，甲苯与顺铂联合作用后，除高频区引起明显的听力损失外，中低频区听力损失更为明显，阈移大于甲苯和顺铂单独作用后阈移的总和。表明甲苯与顺铂联合作用后耳毒性效应呈协同或相加，耳蜗病理亦表明联合作用后外毛细胞受损较明显。
To study the effects of toluene and cisplatin on the hearing of guinea pigs, we found that toluene or cisplatin alone can cause a certain degree of hearing loss in guinea pigs. In addition to the combination of toluene and cisplatin, in addition to causing significant hearing loss in high frequency region, The hearing loss is more obvious, and the threshold shift is greater than the sum of the threshold shifts after the separate action of toluene and cisplatin. It showed that the combined effects of toluene and cisplatin showed synergistic or additive effects of ototoxicity and the pathological changes of cochlear also showed that the damage of outer hair cells was more obvious after combined action.