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目的;研究内毒素血症与慢性肝炎的关系,探讨内毒素在慢性肝炎中的作用机理。方法:收集如下血标本:正常健康献血员30例,慢性乙型肝炎患者30例,慢性深度黄疸乙型肝炎患者60例。采血当日送检功能。分别用鲎实验改良基质法进行内毒素定量测定,放射免疫方法(RIA)测定肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)。结果:内素素、TNF-α、IL-6和总胆红素(TBIL)水平在三组患者中依次升高,各组两两比较,其差异有显著性意义(P<0.01);四项指标进行直线相关性分析,各指标之间呈正相关关系(P<0.01)。结论:内毒素血症与肝脏损害的严重程度有关;内毒素可能主要是通过引起以TNF-α为主的细胞因子水平的升高发挥肝脏损害作用的。
Objective To study the relationship between endotoxemia and chronic hepatitis and explore the mechanism of action of endotoxin in chronic hepatitis. Methods: The following blood samples were collected: 30 normal healthy blood donors, 30 chronic hepatitis B patients and 60 chronic hepatitis B patients with chronic jaundice. Blood sampling function on the day. The levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined by radioimmunoassay (RIA). Results: The level of endothelin, TNF-α, IL-6 and total bilirubin (TBIL) increased in turn among the three groups. There was a significant difference between groups (P <0.01) Linear correlation analysis of indicators, the indicators were positively correlated (P <0.01). CONCLUSION: Endotoxemia is related to the severity of liver damage. Endotoxin may play a role in liver damage mainly through the elevation of TNF-α-induced cytokines.