在北美、欧洲和亚洲,卒中是第3位死亡原因和成人残疾的首要病因[1,2]。颅内动脉粥样硬化所致的卒中约占所有缺血性卒中的8%~10%,据报道,在亚洲、非洲和西班牙裔人群中这一比例更高[3-5]。其危险因素包括胰岛素依赖性糖尿病、高胆固醇血症、高血压和吸烟[6-8]。在美国,估计每年 Stroke was the third leading cause of death and adult disability in North America, Europe and Asia [1,2]. Stroke caused by intracranial atherosclerosis accounts for about 8% to 10% of all ischemic strokes and is reported to be higher in Asian, African and Hispanic populations [3-5]. The risk factors include insulin-dependent diabetes, hypercholesterolemia, hypertension and smoking [6-8]. In the United States, it is estimated that every year