论文部分内容阅读
目的探讨非酒精性脂肪性肝病(NAFLD)患者血清中CK-18水平检测的诊断价值及其与生化指标的相关性。方法选取2014年10月—2016年6月九江学院附属医院收治的NAFLD患者168例为观察组,选择同期在本院进行体检的健康者160例为对照组,分别检测两组受检者血清丙氨酸氨基转移酶(ALT)、γ-谷氨酰胺转肽酶(γ-GT)、天门氨酸氨基转移酶(AST)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)等生化指标以及血清中细胞角蛋白(CK-18)的M30和M65片段水平。结果观察组患者血清γ-GT、AST、TG、LDL-C、FPG、M30和M65水平高于对照组,差异有统计学意义(P<0.05);两组受检者血清ALT、HDL-C水平比较,差异无统计学意义(P>0.05)。Pearson相关分析显示,血清CK-18 M30和M65水平与ALT、γ-GT、AST、TG、LDL-C、HDL-C、FPG呈正相关(P<0.05)。结论血清CK-18片段水平能够准确反映NAFLD患者的病变状态,且与生化指标水平呈正相关。
Objective To investigate the diagnostic value of serum CK-18 in patients with non-alcoholic fatty liver disease (NAFLD) and its correlation with biochemical parameters. Methods A total of 168 NAFLD patients admitted to Jiujiang University Affiliated Hospital from October 2014 to June 2016 were selected as the observation group and 160 healthy subjects in our hospital during the same period were selected as the control group.The levels of serum C ALT, γ-GT, AST, triglyceride (TG), low density lipoprotein cholesterol (LDL-C) (HDL-C), fasting blood glucose (FPG) and other biochemical markers and serum levels of cytokeratin (CK-18) M30 and M65 fragments. Results The serum levels of γ-GT, AST, TG, LDL-C, FPG, M30 and M65 in the observation group were significantly higher than those in the control group (P <0.05) The difference was not statistically significant (P> 0.05). Pearson correlation analysis showed that serum CK-18 M30 and M65 levels were positively correlated with ALT, γ-GT, AST, TG, LDL-C, HDL-C and FPG (P <0.05). Conclusion The serum level of CK-18 can accurately reflect the pathological state of NAFLD patients, and is positively correlated with the level of biochemical markers.