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灯盏花制剂广泛地应用于脑卒中的治疗,以灯盏细辛提取物制备的药物中,咖啡酰奎宁酸类成分的数目、量都不容忽视。因此,对灯盏细辛中咖啡酰奎宁酸类成分的结构、含量、治疗缺血性脑卒中的临床报道以及对相关靶点的药理作用及其机制进行综述。灯盏细辛中已发现22个咖啡酰奎宁酸类化合物,占所有报道的灯盏细辛中化合物的29%;总多酚平均量为36.93%,灯盏细辛注射液中该类成分约占95%以上,高于灯盏乙素;临床研究证实灯盏细辛注射液能提高缺血性脑卒中急性期治疗的有效率,改善神经功能缺损,安全性好;药理研究显示咖啡酰奎宁酸类化合物具有抗氧化、抗自由基、抗凝血、抗炎和抗纤维化等作用,可以保护神经细胞、血管内皮细胞、神经胶质细胞、星形细胞等,抑制炎症因子白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)等,提升超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平,可以在缺血性脑卒中的不同治疗阶段发挥作用,是灯盏细辛中一类值得重视的化学成分。
Breviscapine preparations are widely used in the treatment of stroke, the preparation of the drug Erigeron Breviscapine, caffeoylquinic acid composition of the number, the amount can not be ignored. Therefore, the structure, content of caffeoylquinic acid in Erigeron Breviscapus, the clinical reports of treating ischemic stroke and its pharmacological effects on related targets and its mechanism were reviewed. Erigeron breviscapus 22 caffeoylquinic acid compounds have been found, accounting for 29% of all reported Erigeron breviscapus compounds; the average amount of total polyphenols 36.93%, Erigeron Breviscapus injection of such components accounted for about 95 %, Higher than scutellarin; clinical studies have shown that Erigeron Injection can improve the efficiency of acute stroke ischemic stroke to improve neurological deficit, good safety; pharmacological studies have shown that caffeoylquinic acid compounds Antioxidant, anti-free radical, anticoagulant, anti-inflammatory and anti-fibrosis and other effects, can protect nerve cells, vascular endothelial cells, glial cells, astrocytes, inhibit inflammatory cytokines interleukin-1 -1), tumor necrosis factor-α (TNF-α) and so on, increase the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) Treatment stage to play a role, is a class of Erigeron in a class worthy of attention to the chemical composition.