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目的 探讨自由基在慢性萎缩性胃炎(CAG)病人胃粘膜中的变化及其意义。方法 采用比色法及放射免疫法分别检测了36例CAG病人和17例正常人胃粘膜丙二醛(MDA)含量,胃粘膜超氧化物歧化酶(SOD)含量。结果 CAG病人胃粘膜MDA含量明显升高,胃粘膜SOD含量则明显减少,与正常对照组相比差异有高度显著意义(P<0.01);同时CAG病人胃粘膜MDA含量与胃粘膜SOD含量之间呈负相关,差异并有高度显著意义(P<0.01)。结论 检测自由基对阐明CAG的发病机制可能有重要意义。
Objective To investigate the changes of free radicals in gastric mucosa of patients with chronic atrophic gastritis (CAG) and its significance. Methods Gastric mucosa malondialdehyde (MDA) content and gastric mucosal superoxide dismutase (SOD) content in 36 patients with CAG and 17 normal persons were detected by colorimetric method and radioimmunoassay respectively. Results The content of MDA in gastric mucosa was significantly increased in CAG patients and the content of SOD in gastric mucosa was significantly decreased (P <0.01). Meanwhile, there was a significant difference between the content of MDA in gastric mucosa and the content of SOD in gastric mucosa Was negatively correlated, the difference was highly significant (P <0.01). Conclusion The detection of free radicals may be of great significance to elucidate the pathogenesis of CAG.