论文部分内容阅读
目的报道1例临床活体肝部分移植受体的免疫抑制治疗情况。方法1997年6月30日 ,我科成功地施行了1例活体肝部分移植术 ,术后采用皮质激素、硫唑嘌呤、环孢素A三联免疫抑制治疗 ,并监测环孢素A的血药浓度。术后第10天 ,发生急性移植排斥反应 ,经皮质激素冲击治疗及增加环孢素A的用量后 ,排斥反应被逆转。在恢复期 ,采用小剂量的环孢素A和骁悉维持治疗。结果目前患者一般情况良好 ,已健康生存2年9个月。结论活体肝部分移植术 ,对于终末期肝病患者是一种较好的治疗手段 ,采用三联免疫抑制治疗可预防和逆转排斥反应。而且 ,与尸肝移植相比较 ,免疫抑制剂用量较小、疗程短、副作用少 ,患者恢复较为顺利。
Objective To report the immunosuppressive treatment of 1 case of living donor liver partial graft. Methods June 30, 1997, our department successfully administered a living partial liver transplantation, postoperative use of corticosteroids, azathioprine, cyclosporine A triple immunosuppressive therapy and monitoring of cyclosporine A blood drug concentration. On the 10th postoperative day, an acute graft rejection occurred and the rejection reaction was reversed after corticosteroid treatment and cyclosporin A administration. During recovery, use a small dose of cyclosporine A and carbaryl maintenance therapy. Results The patient is generally in good condition and has been healthy for 2 years and 9 months. Conclusion Partial living donor liver transplantation is a good treatment for patients with end-stage liver disease. Triple immunosuppressive therapy can prevent and reverse the rejection. Moreover, compared with the dead liver transplantation, immunosuppressive agents in smaller doses, short course, fewer side effects, the patient recovered more smoothly.