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目的观察神经元特异性烯醇化酶(NSE)在颅内感染患者血清和脑脊液中的含量变化并探讨其意义。方法应用放免法测定55例颅内感染患者:病毒性脑炎(病脑)20例,结核性脑膜炎(结脑)19例,化脓性脑膜炎(化脑)13例和对照组20例的血清及脑脊液中NSE含量。结果无论在脑脊液还是在血清中观察组的NSE含量均显著高于对照组(P<0.05);NSE含量依次为病脑>结脑>化脑(P<0.05);血清和脑脊液中含量呈正相关(P<0.01)。结论颅内感染患者血清和脑脊液中NSE含量与脑损害程度密切相关;测定血清中NSE含量可以做为判断脑损害程度的观察指标。
Objective To investigate the changes of neuron specific enolase (NSE) in serum and cerebrospinal fluid of patients with intracranial infection and to explore its significance. Methods 55 cases of intracranial infection were detected by radioimmunoassay: 20 cases of viral encephalitis (sick brain), 19 cases of tuberculous meningitis (tuberculous meningitis), 13 cases of purulent meningitis (mesencephalic brain) and 20 cases of control group Serum and CSF NSE levels. Results NSE levels in the observation group were significantly higher than those in the control group (P <0.05). NSE content was in the order of sick brain> brain> brain (P <0.05), and there was a positive correlation between serum and cerebrospinal fluid (P <0.01). Conclusion The serum levels of NSE in serum and cerebrospinal fluid of patients with intracranial infection are closely related to the degree of brain damage. Determination of serum NSE levels can be used as an indicator of brain damage.