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目的观察莫西沙星三联疗法治疗根治失败的幽门螺杆菌(Hp)感染的临床疗效及药物的不良反应。方法选取常规Hp根治失败的患者125例随机分成A、B两组,A组64例给予莫西沙星0.4g qd+泮托拉唑0.4g bid+阿莫西林1.0g bid;B组61例给予泮托拉唑0.4g bid+枸盐酸铋钾0.22g bid+呋喃唑酮0.2g bid+阿莫西林1.0g bid,A、B两组均服药1周。两组停服质子泵抑制剂及抗菌素4周后行~(14)C-BUT呼气试验检测Hp感染是否根治。结果 A、B两组的根治率分别为90.5%和75.4%(P<0.05);不良反应发生率分别为9.4%和22.8%(P<0.05)。A组比B组多支付医疗费用137.9元。结论莫西沙星三联疗法治疗根治失败的Hp感染是一种有效,安全的治疗方案。
Objective To observe the clinical efficacy and adverse drug reactions of moxifloxacin triple therapy in the treatment of helicobacter pylori (Hp) infection. Methods A total of 125 patients with failed radical Hp were randomly divided into two groups: group A (64 cases), moxifloxacin (0.4g qd + pantoprazole 0.4g bid + amoxicillin 1.0g bid), group B (61 cases) Lazole 0.4g bid + bismuth potassium citrate 0.22g bid + furazolidone 0.2g bid + amoxicillin 1.0g bid, A, B two groups were taking 1 week. Two groups stopped taking proton pump inhibitors and antibiotics 4 weeks after ~ (14) C-BUT breath test to detect Hp infection is radical. Results The cure rates of group A and B were 90.5% and 75.4% respectively (P <0.05). The incidence of adverse reactions were 9.4% and 22.8% respectively (P <0.05). A group paid more than B group medical costs 137.9 yuan. Conclusion Moxifloxacin triple therapy for the treatment of Hp infection failed to cure is an effective and safe treatment.