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目的:利用Meta分析方法评价丹参酮Ⅱ_A注射液治疗脑梗死的疗效和安全性。方法:检索国内、外公开发表的关于丹参酮Ⅱ_A注射液治疗急性脑梗死临床试验文献,利用RevMan 4.2软件对纳入文献进行Meta分析。结果:采用固定效应模型对10个研究做Meta分析,丹参酮Ⅱ_A注射液治疗脑梗死的有效性与对照组比较,差异有统计学意义;丹参酮Ⅱ_A注射液治疗脑梗死的不良反应与对照组比较,差异无统计学意义。结论:丹参酮Ⅱ_A注射液治疗脑梗死安全、有效。
Objective: To evaluate the efficacy and safety of tanshinone Ⅱ_A injection in the treatment of cerebral infarction by Meta-analysis. Methods: The domestic and foreign published clinical trials on the treatment of acute cerebral infarction with tanshinone Ⅱ_A injection were performed, and Meta-analysis was performed on RevMan 4.2 software. Results: Meta-analysis of 10 studies using fixed effect model, tanshinone Ⅱ_A injection of cerebral infarction compared with the control group, the difference was statistically significant; Tanshinone Ⅱ_A injection of cerebral infarction adverse reactions compared with the control group, The difference was not statistically significant. Conclusion: Tanshinone Ⅱ_A injection is safe and effective in treating cerebral infarction.