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目的 探讨左炔诺孕酮宫内缓释系统(LNG-IUS)对子宫内膜息肉电切术(TC RP)术后患者子宫内膜组织胰岛素样生长因子-Ⅰ(IGF-Ⅰ)及其受体(IGF-IR)表达的影响.方法 选取100例子宫内膜息肉(EP)患者,对照组(n=50)仅给予TCRP治疗,观察组(n=50)TCRP术后给予LNG-IUS治疗.比较两组患者月经失血图(PBCA)评分、子宫内膜厚度、术后复发率、子宫内膜组织IGF-Ⅰ和IGF-IR mRNA表达水平.结果 术后1、3、6、12个月,观察组PBAC评分、子宫内膜厚度均显著小于对照组(P≤0.05).术后12个月,观察组子宫内膜组织IGF-Ⅰ和IGF-IR mRNA表达水平均显著低于对照组(P≤0.05).术后随访12个月,对照组和观察组复发率分别为16.0％ (8/50)、4.0％ (2/50),观察组术后复发率显著低于对照组(P≤0.05).结论 TCRP术后联合LNG-IUS治疗可明显降低EP复发,而下调IGF-Ⅰ及IGF-IR mRNA表达是其可能作用机制.“,”Objective To evaluate the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) on insulin-like growth factor-Ⅰ (IGF-Ⅰ) and insulin-like growth factor-Ⅰ receptor (IGF-IR) expression after transcervical resection of polyp (TCRP).Methods 100 cases of endometrial polyps were selected.The control group (n =50) was treated with TCRP only,while the observation group (n =50) was treated with LNG-IUS after TCRP.The scores of pictorial blood loss assessment chart (PBCA),endometrial thickness,recurrence rate,mRNA expression of IGF-Ⅰ and IGF-IR in endometrial tissue were compared between the two groups.Results At 1,3,6,12 months follow-up,the PBAC score and endometrial thickness of observation group were significantly lower than control group (P ≤ 0.05).At 12 months after operation,the mRNA expression levels of IGF-Ⅰ and IGF-IR in the endometrium of the observation group were significantly lower than those of the control group (P ≤ 0.05).After 12 months of follow-up,the recurrence rates of the control group and the observation group were 16.0％ (8/50) and 4.0％ (2/50),respectively.The recurrence rate of the observation group was significantly lower than that of the control group (P ≤ 0.05).Conclusions TCRP combined with LNG-IUS treatment can significantly reduce EP recurrence,and down-regulation of the mRNA expression of IGF-Ⅰ and IGF-IR maybe its possible mechanism.